DNA methylation inhibition increases T cell KIR expression through effects on both promoter methylation and transcription factors

Killer-cell immunoglobulin-like receptor (KIR) genes are a polymorphic family expressed on NK cells, and "senescent" CD28- T cells implicated in cardiovascular disease. KIR promoters are highly homologous, and NK expression is regulated by DNA methylation. T cell KIR regulation is poorly u...

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Bibliographische Detailangaben

Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 130(2009), 2 vom: 11. Feb., Seite 213-24
1. Verfasser:	Liu, Ying (VerfasserIn)
Weitere Verfasser:	Kuick, Rork, Hanash, Samir, Richardson, Bruce
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2009
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Enzyme Inhibitors RNA, Messenger Receptors, KIR2DL4 Receptors, KIR3DL2 Trans-Activators Azacitidine M801H13NRU