Hyperexpression of NOD2 in intestinal mast cells of Crohn's disease patients : preferential expression of inflammatory cell-recruiting molecules via NOD2 in mast cells

NOD2, an intracellular sensor of bacteria-derived muramyl dipeptide (MDP) has been implicated as a key player in intestinal immune health and disease. Mast cells (MCs) have been reported to be increased in the gut of patients with inflammatory bowel disease. However, NOD2 expression and its role in...

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Détails bibliographiques

Publié dans:	Clinical immunology (Orlando, Fla.). - 1999. - 130(2009), 2 vom: 15. Feb., Seite 175-85
Auteur principal:	Okumura, Shigeru (Auteur)
Autres auteurs:	Yuki, Keisuke, Kobayashi, Ryota, Okamura, Shinichi, Ohmori, Kazumitsu, Saito, Hirohisa, Ra, Chisei, Okayama, Yoshimichi
Format:	Article en ligne
Langue:	English
Publié:	2009
Accès à la collection:	Clinical immunology (Orlando, Fla.)
Sujets:	Journal Article Research Support, Non-U.S. Gov't Biomarkers CXCL10 protein, human Chemokine CXCL10 Nod2 Signaling Adaptor Protein Acetylmuramyl-Alanyl-Isoglutamine 53678-77-6