Myelin basic protein-specific T lymphocytes proliferation and programmed cell death in demyelinating diseases

Myelin basic protein-specific T lymphocytes proliferation and programmed cell death in demyelinating diseases

A dynamic equilibrium between proliferation and programmed cell death (PCD) of auto-reactive T lymphocytes plays a pivotal role in the prevention of autoimmune diseases. We analyzed T lymphocytes myelin basic protein (MBP)-specific PCD and proliferation in demyelinating diseases. Results showed that...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 3 vom: 15. Dez., Seite 509-17
1. Verfasser: Saresella, Marina (VerfasserIn)
Weitere Verfasser: Marventano, Ivana, Guerini, Franca Rosa, Zanzottera, Milena, Delbue, Serena, Marchioni, Enrico, Maserati, Renato, Longhi, Renato, Ferrante, Pasquale, Clerici, Mario
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Cytokines DNA, Viral Myelin Basic Protein Peptide Fragments
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520 |a A dynamic equilibrium between proliferation and programmed cell death (PCD) of auto-reactive T lymphocytes plays a pivotal role in the prevention of autoimmune diseases. We analyzed T lymphocytes myelin basic protein (MBP)-specific PCD and proliferation in demyelinating diseases. Results showed that MBP-specific PCD was significantly decreased in CD4+ and CD8+ T lymphocytes of progressive multifocal leukoencephalopathy (PML), not determined leukoencephalopathy (NDLE), and acute MS (AMS) patients compared to patients with stable MS (SMS) and healthy controls. MBP-specific proliferation/PCD rates were high in CD4+ T lymphocytes of PML, NDLE, and AMS patients, and in CD8+ T cells of PML and AMS individuals alone. Alterations of the balance between MBP-specific proliferation and PCD are present in demyelinating diseases and could play a major role in the pathogenesis of these diseases 
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700 1 |a Marventano, Ivana  |e verfasserin  |4 aut 
700 1 |a Guerini, Franca Rosa  |e verfasserin  |4 aut 
700 1 |a Zanzottera, Milena  |e verfasserin  |4 aut 
700 1 |a Delbue, Serena  |e verfasserin  |4 aut 
700 1 |a Marchioni, Enrico  |e verfasserin  |4 aut 
700 1 |a Maserati, Renato  |e verfasserin  |4 aut 
700 1 |a Longhi, Renato  |e verfasserin  |4 aut 
700 1 |a Ferrante, Pasquale  |e verfasserin  |4 aut 
700 1 |a Clerici, Mario  |e verfasserin  |4 aut 
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