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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.08.012
|2 doi
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|a pubmed24n0609.xml
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|a (NLM)18824414
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Cai, Lun
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 04.12.2008
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|a Date Revised 08.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Functional defects in natural killer (NK) cells have been proposed to be responsible for the failure of anti-tumor immune responses. Whether and how NK cells are impaired in hepatocellular carcinoma (HCC) patients remain unknown. In this study, we found that HCC patients displayed a dramatic reduction in peripheral CD56(dim)CD16(pos) NK subsets compared with healthy subjects. A significant reduction of CD56(dim)CD16(pos) NK subsets was also found in tumor regions compared with non-tumor regions in the livers of these HCC patients. Both these peripheral and tumor-infiltrating NK cells exhibited poorer capacity to produce IFN-gamma and kill K562 targets, which was further found to be associated with increased CD4(+)CD25(+) T regulatory cells as we previously-described in HCC patients. Addition of Tregs from HCC patients efficiently inhibited the anti-tumor ability of autologous NK cells in vitro. These findings are helpful for understanding the mechanism of NK cell-mediated anti-tumor immune responses in HCC patients
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a CD56 Antigen
|2 NLM
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| 650 |
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|a FCGR3B protein, human
|2 NLM
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| 650 |
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|a GPI-Linked Proteins
|2 NLM
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| 650 |
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|a Receptors, IgG
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Zhang, Zheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Haiyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fu, Junliang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Shuye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Min
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Yongping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Hao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tien, Po
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Fu-Sheng
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 129(2008), 3 vom: 15. Dez., Seite 428-37
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:129
|g year:2008
|g number:3
|g day:15
|g month:12
|g pages:428-37
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|u http://dx.doi.org/10.1016/j.clim.2008.08.012
|3 Volltext
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