2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model

Patients with asthma experience airway structural changes, termed airway remodeling, in response to persistent inflammation. 2-Methoxyestradiol (2-ME) is an anti-angiogenic agent and downregulates hypoxia-inducible factor 1 (HIF-1) and inhibits HIF-1alpha-induced transcriptional activation of vascul...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 2 vom: 01. Nov., Seite 313-24
1. Verfasser:	Huerta-Yepez, S (VerfasserIn)
Weitere Verfasser:	Baay-Guzman, G J, Garcia-Zepeda, R, Hernandez-Pando, R, Vega, M I, Gonzalez-Bonilla, C, Bonavida, B
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2008
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Collagen Type IV Hif1a protein, mouse Hypoxia-Inducible Factor 1, alpha Subunit Vascular Endothelial Growth Factor A Immunoglobulin E 37341-29-0 Estradiol mehr... 4TI98Z838E 2-Methoxyestradiol 6I2QW73SR5 Ovalbumin 9006-59-1