Nifedipine suppresses Th1/Th2 cytokine production and increased apoptosis of anti-CD3 + anti-CD28-activated mononuclear cells from patients with systemic lupus erythematosus via calcineurin pathway
Increased Ca(2+) influx is found in mononuclear cells (MNC) of patients with systemic lupus erythematosus (SLE). The role of calcineurin and potential implication of calcium channel blocker to suppress the abnormal Ca(2+) influx in SLE remain to be determined. In the present study, we found that the...
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Bibliographische Detailangaben
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 3 vom: 10. Dez., Seite 462-70
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| 1. Verfasser: |
Lu, Ming-Chi
(VerfasserIn) |
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| Weitere Verfasser: |
Lai, Ning-Sheng,
Yu, Hui-Chun,
Hsieh, Song-Chou,
Tung, Chien-Hsueh,
Yu, Chia-Li |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2008
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.)
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
Adaptor Proteins, Signal Transducing
CABIN1 protein, human
CD28 Antigens
CD3 Complex
Calcium Channel Blockers
Calcium Channels, L-Type
Cytokines
FASLG protein, human
mehr...
Fas Ligand Protein
NFATC Transcription Factors
NFATC1 protein, human
Interleukin-10
130068-27-8
Interferon-gamma
82115-62-6
Calcineurin
EC 3.1.3.16
Phosphoric Monoester Hydrolases
EC 3.1.3.2
Nifedipine
I9ZF7L6G2L |
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