Role of the coagulation system in allergic inflammation in the upper airways

Thrombin has been detected and demonstrated to play a role in the airways of patients with bronchial asthma, but its role in the upper airways including during allergic rhinitis is unknown. This study was conducted to explore whether thrombin is presence in the upper airways and, if so, whether it a...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 2 vom: 19. Nov., Seite 365-71
1. Verfasser:	Shimizu, Shino (VerfasserIn)
Weitere Verfasser:	Shimizu, Takeshi, Morser, John, Kobayashi, Tetsu, Yamaguchi, Aiko, Qin, Liqiang, Toda, Masaaki, D'Alessandro-Gabazza, Corina, Maruyama, Takaya, Takagi, Takehiro, Yano, Yutaka, Sumida, Yasuhiro, Hayashi, Tatsuya, Takei, Yoshiyuki, Taguchi, Osamu, Suzuki, Koji, Gabazza, Esteban C
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2008
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article MUC5AC protein, human Muc5ac protein, rat Mucin 5AC Mucins Protein C Receptor, PAR-1 Thromboplastin 9035-58-9 Thrombin EC 3.4.21.5

Beschreibung
Zusammenfassung:	Thrombin has been detected and demonstrated to play a role in the airways of patients with bronchial asthma, but its role in the upper airways including during allergic rhinitis is unknown. This study was conducted to explore whether thrombin is presence in the upper airways and, if so, whether it affects mucin secretion. Fifteen patients with allergic rhinitis were enrolled in the clinical study; primary nasal septum epithelial cells and normal bronchial epithelial cells were used for in vitro evaluation, and rats as animal models. Significant concentrations of thrombin were found in nasal secretion after allergic provocation in allergic patients, and thrombin and its agonistic receptor peptide induced significant secretion of mucin in primary nasal cells and normal bronchial epithelial cells as compared to non-stimulated cells. Increased mucosubstance secretion in septum epithelial cells was also induced after nasal instillation of thrombin in rats. Further, the anticoagulant, activated protein C, significantly inhibited thrombin-induced mucin secretion from septum epithelial cells in rats. The results of this study suggest that activation of the coagulation system occurs during the allergic response and that thrombin plays a crucial role in the regulation of mucin production in the upper airways
Beschreibung:	Date Completed 06.11.2008 Date Revised 01.12.2018 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2008.07.020