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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1021/la8016563
|2 doi
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|a pubmed25n0608.xml
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|a (NLM)18785722
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|a DE-627
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|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Gonzalez-Lopez, Jaime
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Self-associative behavior and drug-solubilizing ability of poloxamine (tetronic) block copolymers
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| 264 |
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|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 28.10.2008
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The incidence of the structural features on the self-assembly of different poloxamines (the conventional sequential Tetronic 304, 901, 904, 908, 1107, 1301, and 1307; a reverse-sequential counterpart Tetronic 150R1; and a chemically modified derivative, N-methylated Tetronic 1107) was thoroughly studied in 10 mM HCl by means of pi-A isotherm, surface tension, and pyrene fluorescence measurements. The size and size distribution of the aggregates were investigated by dynamic and static light scattering, and the morphology was probed by transmission electron microscopy. The abilities of the different derivatives to solubilize the drug simvastatin were also evaluated. Poloxamines with both higher PO/EO ratio and molecular weight (T1301 and T150R1) led to micelles with larger and more hydrophobic cores, particularly adequate for hosting hydrophobic molecules and protecting the labile lactone form of simvastatin from hydrolysis. On the other hand, the hydroxy acid form of simvastatin interacted with the central ethylenediamine group under alkaline pH (T304) or when a permanent positive charge due to methylation was present. Micelles of long poloxamine molecules containing large PPO blocks (with 23-29 units, namely, T1301, T1307, and T150R1), particularly the one that also has long PEO blocks, were the most physically stable toward dilution
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Ethylenediamines
|2 NLM
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| 650 |
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|a Micelles
|2 NLM
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| 650 |
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|a Polymers
|2 NLM
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| 650 |
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|a Simvastatin
|2 NLM
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| 650 |
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7 |
|a AGG2FN16EV
|2 NLM
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| 700 |
1 |
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|a Alvarez-Lorenzo, Carmen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Taboada, Pablo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sosnik, Alejandro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sandez-Macho, Isabel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Concheiro, Angel
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1991
|g 24(2008), 19 vom: 07. Okt., Seite 10688-97
|w (DE-627)NLM098181009
|x 0743-7463
|7 nnns
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| 773 |
1 |
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|g volume:24
|g year:2008
|g number:19
|g day:07
|g month:10
|g pages:10688-97
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|u http://dx.doi.org/10.1021/la8016563
|3 Volltext
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