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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.07.006
|2 doi
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|a pubmed24n0608.xml
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|a (DE-627)NLM182241645
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|a (NLM)18771958
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Li, Hsing-Hui
|e verfasserin
|4 aut
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| 245 |
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|a Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 06.11.2008
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|a Date Revised 11.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Lupus nephritis is one manifestation of systemic lupus erythematosus (SLE). Interleukin (IL)-10 is involved in the pathogenesis of SLE. To determine whether IL-20, a member of the IL-10 family, is associated with lupus nephritis, we analyzed the expression of IL-20 and its receptors in mesangial cells derived from SLE-prone, NZB/W, and DBA/W mice. IL-20 and its receptors were upregulated in mesangial cells from NZB/W mice. Incubating IL-20 with mesangial cells upregulated the transcripts of CCL2 (MCP-1), CCL5 (RANTES), CXCL10 (IP-10), IL-6, iNOS, and ROS, all of which are involved in the pathogenesis of lupus nephritis. IL-20 specifically activated the downstream signal ERK 1/2. We also detected human IL-20 protein in both mesangial cells and inflammatory cells in kidney biopsies of patients with lupus nephritis. Our results reveal the novel effects of IL-20 on mesangial cells and its association with lupus nephritis
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Chemokines
|2 NLM
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|a Cytokines
|2 NLM
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| 650 |
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|a Interleukins
|2 NLM
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|a Reactive Oxygen Species
|2 NLM
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|a Nitric Oxide Synthase Type II
|2 NLM
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| 650 |
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|a EC 1.14.13.39
|2 NLM
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| 650 |
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|a Extracellular Signal-Regulated MAP Kinases
|2 NLM
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| 650 |
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|a EC 2.7.11.24
|2 NLM
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| 650 |
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|a interleukin 20
|2 NLM
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| 650 |
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|a U91R7IMG8U
|2 NLM
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| 700 |
1 |
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|a Cheng, He-Hsiung
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Kuang-Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wei, Chi-Chen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Chien-Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Wen-Chung
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Wen-Mein
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chang, Ming-Shi
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 129(2008), 2 vom: 19. Nov., Seite 277-85
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:129
|g year:2008
|g number:2
|g day:19
|g month:11
|g pages:277-85
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|u http://dx.doi.org/10.1016/j.clim.2008.07.006
|3 Volltext
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