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231223s2008 xx |||||o 00| ||eng c |
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7 |
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|a 10.1021/la801179v
|2 doi
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|a pubmed24n0607.xml
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|a (NLM)18767822
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Ng, Jovice B S
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Release and molecular transport of cationic and anionic fluorescent molecules in mesoporous silica spheres
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| 264 |
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|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 28.10.2008
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|a Date Revised 03.10.2008
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a We describe here a method for study of bulk release and local molecular transport within mesoporous silica spheres. We have analyzed the loading and release of charged fluorescent dyes from monodisperse mesoporous silica (MMS) spheres with an average pore size of 2.7 nm. Two different fluorescent dyes, one cationic and one anionic, have been loaded into the negatively charged porous material and both the bulk release and the local molecular transport within the MMS spheres have been quantified by confocal laser scanning microscopy. Analysis of the time-dependent release and the concentration profiles of the anionic dye within the spheres show that the spheres are homogeneous and that the release of this nonadsorbing dye follows a simple diffusion-driven process. The concentration of the cationic dye varies radially within the MMS spheres after loading; there is a significantly higher concentration of the dye close to the surface of the spheres (forming a "skin") compared to that at the core. The release of the cationic dye is controlled by diffusion after an initial period of rapid release. The transport of the cationic dye within the MMS spheres of the dye from the core to near the surface is significantly faster compared to the transport within the surface "skin". A significant fraction of the cationic dye remains permanently attached to the negatively charged walls of the MMS spheres, preferentially near the surface of the spheres. Relating bulk release to the local molecular transport within the porous materials provides an important step toward the design of new concepts in controlled drug delivery and chromatography
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Anions
|2 NLM
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|a Cations
|2 NLM
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|a Fluorescent Dyes
|2 NLM
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|a Silicon Dioxide
|2 NLM
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| 650 |
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|a 7631-86-9
|2 NLM
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| 700 |
1 |
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|a Kamali-Zare, Padideh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Brismar, Hjalmar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bergström, Lennart
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 24(2008), 19 vom: 07. Okt., Seite 11096-102
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:24
|g year:2008
|g number:19
|g day:07
|g month:10
|g pages:11096-102
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|u http://dx.doi.org/10.1021/la801179v
|3 Volltext
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