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|a 10.1111/j.1939-165X.2008.00048.x
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|a eng
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| 100 |
1 |
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|a Foglia Manzillo, Valentina
|e verfasserin
|4 aut
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| 245 |
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|a Extranodal gammadelta-T-cell lymphoma in a dog with leishmaniasis
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| 264 |
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|c 2008
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| 336 |
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 18.11.2008
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|a Date Revised 01.12.2018
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a An 8-year-old intact male mongrel dog with alopecia and weight loss was referred to the Veterinary Faculty of Naples. The dog had pale mucous membranes, enlarged prescapular lymph nodes, and splenomegaly. Laboratory abnormalities included anemia, thrombocytopenia, and hyperglobulinemia. Bone marrow aspirate smears contained numerous Leishmania amastigotes and an immunofluorescent antibody titer was strongly positive (1:1280) for leishmaniasis. The dog was treated with a combination of meglumine antimoniate and allopurinol for 60 days and showed clinical improvement. Two months after the end of treatment the dog was again referred because of relapse of leishmaniasis and the presence of a firm subcutaneous mass on the medial right thigh. Based on cytologic examination of fine needle aspirates of the mass, a diagnosis of large-cell lymphoma was made. Flow cytometry of tumor cells revealed gammadelta-T-cell lymphoma with a CD5+, CD3+, TCRgammadelta+, CD4-, CD8-, CD45RA+ immunophenotype. Using nested PCR, amastigotes were not detected in the neoplastic tissue. An association between leishmaniasis and hematopoietic tumors has been described rarely. gammadelta-T cells may be involved in the host response to this parasite, and prolonged antigenic stimulation and chronic immunosuppression (typical of leishmaniasis) play a crucial role in the etiopathogenesis of T-cell lymphoma
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|a Case Reports
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|a Journal Article
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|a Antiprotozoal Agents
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|a Organometallic Compounds
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|a Allopurinol
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| 700 |
1 |
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|a Pagano, Annalisa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guglielmino, Roberta
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gradoni, Luigi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Restucci, Brunella
|e verfasserin
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| 700 |
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|a Oliva, Gaetano
|e verfasserin
|4 aut
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|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 37(2008), 3 vom: 24. Sept., Seite 298-301
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|x 1939-165X
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|g volume:37
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