Altered expression of the costimulatory molecules CD80, CD86, CD152, PD-1 and ICOS on T-cells from paracoccidioidomycosis patients : lack of correlation with T-cell hyporesponsiveness

T-cell proliferative hyporesponsiveness, a hallmark of paracoccidioidomycosis immune responses, underlies host's failure in controlling fungus spread, being reversible with antifungal treatment. The mechanisms leading to this hypoproliferation are not well known. Since costimulatory molecules h...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 2 vom: 04. Nov., Seite 341-9
1. Verfasser: Cacere, Camila R (VerfasserIn)
Weitere Verfasser: Mendes-Giannini, Maria J S, Fontes, Cor J, Kono, Adriana, Duarte, Alberto J S, Benard, Gil
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigens, CD Antigens, Differentiation, T-Lymphocyte Apoptosis Regulatory Proteins B7-1 Antigen B7-2 Antigen CTLA-4 Antigen CTLA4 protein, human ICOS protein, human mehr... Inducible T-Cell Co-Stimulator Protein PDCD1 protein, human Programmed Cell Death 1 Receptor