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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1021/la801695j
|2 doi
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|a pubmed25n0605.xml
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|a eng
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1 |
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|a Jain, Vikas
|e verfasserin
|4 aut
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| 245 |
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|a Dynamic surface activity by folding and unfolding an amphiphilic alpha-helix
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|c 2008
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 17.10.2008
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|a Date Revised 22.03.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a We describe a rationally designed peptide with tunable surface activity, where the dynamics of surface activity are an outcome of helical folding. Our rationally designed model peptide is surface-active only as an alpha-helix. We apply circular dichroism to show that the folded population can be controlled with changes in electrolyte concentration, and we apply pendant bubble tensiometry to explore dynamic surfactant activity. This study shows a peptide that responds to environmental stimuli with dynamic folding and surface activity. Extending this concept to selective binding peptides will lead to new tools, where dynamic surface activity is coupled to targeted binding
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Jimenez, Angela
|e verfasserin
|4 aut
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|a Maldarelli, Charles
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tu, Raymond S
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1991
|g 24(2008), 18 vom: 16. Sept., Seite 9923-8
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|x 0743-7463
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|g volume:24
|g year:2008
|g number:18
|g day:16
|g month:09
|g pages:9923-8
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|u http://dx.doi.org/10.1021/la801695j
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