A role for Fli-1 in B cell proliferation : implications for SLE pathogenesis

Transgenic overexpression of Fli-1 in normal mice leads to SLE-like disease and increased expression was reported in SLE-affected human and murine lymphocytes. Reducing Fli-1 expression in MRL/lpr mice decreased antibody production, proteinuria, renal pathology, and mortality. Compared to those with...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 1 vom: 01. Okt., Seite 19-30
1. Verfasser:	Bradshaw, Sarah (VerfasserIn)
Weitere Verfasser:	Zheng, W Jim, Tsoi, Lam C, Gilkeson, Gary, Zhang, Xian K
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2008
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Fli1 protein, mouse Il12a protein, mouse Interleukin-12 Subunit p35 NFATC Transcription Factors Proto-Oncogene Protein c-fli-1 Receptors, Antigen, B-Cell Toll-Like Receptor 4 Toll-Like Receptor 9