TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients

TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients

Plasmacytoid dendritic cells (pDCs) can produce a large amount of interferon-alpha (IFN-alpha) upon exposure to TLR9 or TLR7 agonists. Human pDCs have been shown to play an important role in the pathogenesis of systemic lupus erythematosus (SLE) through increased production of IFN-alpha. So, how to...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 1 vom: 01. Okt., Seite 40-8
1. Verfasser: Wu, Pingping (VerfasserIn)
Weitere Verfasser: Wu, Jiang, Liu, Shuxun, Han, Xinghai, Lu, Jianqiang, Shi, Yeqing, Wang, Jianli, Lu, Liwei, Cao, Xuetao
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigen-Antibody Complex CLEC4C protein, human CPG-oligonucleotide Cytokines Lectins, C-Type Membrane Glycoproteins Oligodeoxyribonucleotides Receptors, Immunologic mehr... Toll-Like Receptor 7 Toll-Like Receptor 9
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