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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1021/la801190z
|2 doi
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|a pubmed25n0605.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Shen, Lei
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Kinetics of pH-Induced formation and dissociation of polymeric vesicles assembled from a water-soluble zwitterionic diblock copolymer
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 17.10.2008
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|a Date Revised 10.09.2008
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The kinetics of pH-induced formation and dissociation of vesicles self-assembled from a biocompatible zwitterionic diblock copolymer, poly(2-(methacryloyloxy)ethyl phosphorylcholine)-b-poly(2-(diisopropylamino)ethyl methacrylate) (PMPC- b-PDPA), was investigated in detail via a combination of stopped-flow light scattering and laser light scattering (LLS). Upon jumping from pH 2 to 10, stopped-flow light scattering reveals three distinct relaxation processes for the early stages of vesicle self-assembly (0-40 s). Kinetic sequences associated with the obtained three characteristic relaxation times have been tentatively proposed. Moreover, the kinetics of vesicle formation in the later stage (from 3 min onward) was investigated by dynamic LLS. It was found that both the intensity-averaged hydrodynamic radius, R h, and the polydispersity, mu2/Gamma (2), decrease exponentially, yielding a characteristic relaxation time of approximately 350 s. To our knowledge, this is the first report on the kinetics of the unimer-to-vesicle transition of a stimulus-responsive diblock copolymer. The kinetics of vesicle dissociation for a pH jump from 12 to 2 was also investigated. The breakdown of polymeric vesicles is extremely fast and is independent of polymer concentration; it is complete within approximately 5 ms and is in marked contrast to the much slower rate of vesicle formation
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Ions
|2 NLM
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|a Polymers
|2 NLM
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1 |
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|a Du, Jianzhong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Armes, Steven P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Shiyong
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 24(2008), 18 vom: 16. Sept., Seite 10019-25
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
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|g volume:24
|g year:2008
|g number:18
|g day:16
|g month:09
|g pages:10019-25
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| 856 |
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|u http://dx.doi.org/10.1021/la801190z
|3 Volltext
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