ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease

Chronic granulomatous disease is an immunodeficiency caused by an inability to produce reactive oxygen species. While the mechanism of hyper-sensitivity to infection is well understood in CGD, the basis for debilitating inflammatory disorders that arise in the absence of evident infection has not be...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 1 vom: 03. Okt., Seite 90-102
1. Verfasser:	Brown, Kelly L (VerfasserIn)
Weitere Verfasser:	Bylund, Johan, MacDonald, Kelly L, Song-Zhao, George X, Elliott, Melissa R, Falsafi, Reza, Hancock, Robert E W, Speert, David P
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2008
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Cytokines Inflammation Mediators Reactive Oxygen Species Toll-Like Receptors Protein Serine-Threonine Kinases EC 2.7.11.1 Extracellular Signal-Regulated MAP Kinases EC 2.7.11.24 p38 Mitogen-Activated Protein Kinases