PDL-1 upregulation on monocytes and T cells by HIV via type I interferon : restricted expression of type I interferon receptor by CCR5-expressing leukocytes

The programmed death (PD)-1 interacts with its ligand (PDL-1) delivering a negative signal to T cells. During human immunodeficiency virus (HIV)-1 infection PD-1 and PDL-1 expressions are increased. Here we show that monocytes and CCR5(+) T cells of HIV-uninfected donors upregulated PDL-1 upon in vi...

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Détails bibliographiques

Publié dans:	Clinical immunology (Orlando, Fla.). - 1999. - 129(2008), 1 vom: 15. Okt., Seite 132-44
Auteur principal:	Boasso, Adriano (Auteur)
Autres auteurs:	Hardy, Andrew W, Landay, Alan L, Martinson, Jeffrey L, Anderson, Stephanie A, Dolan, Matthew J, Clerici, Mario, Shearer, Gene M
Format:	Article en ligne
Langue:	English
Publié:	2008
Accès à la collection:	Clinical immunology (Orlando, Fla.)
Sujets:	Journal Article Research Support, N.I.H., Intramural Antigens, CD B7-1 Antigen B7-2 Antigen B7-H1 Antigen CD274 protein, human IFNAR2 protein, human Interferon Type I Receptors, CCR5 plus... Toll-Like Receptors Receptor, Interferon alpha-beta 156986-95-7