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01000naa a22002652 4500 |
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NLM180972383 |
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DE-627 |
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20231223160416.0 |
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tu |
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231223s2008 xx ||||| 00| ||jpn c |
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|a pubmed24n0603.xml
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a jpn
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| 100 |
1 |
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|a Kobayashi, Shuichiro
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Estramustine phosphate withdrawal syndrome in relapsed prostate cancer
|b two case reports
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| 264 |
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1 |
|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 03.09.2008
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a The decrease of the level of serum prostate specific antigen (PSA) after discontinuation of estramustine phosphate (EMP) has rarely been reported. We report 2 cases in whom EMP withdrawal syndrome was encountered. Case 1 was a 68-year-old man with a complaint of paresis of lower limbs. He was diagnosed with prostate cancer with multiple bone metastases. The serum PSA level was 9,300 ng/ml. He was treated with luteinizing hormone-releasing hormone agonist (LH-RHa) and bicalutamide (BCL). Six months later, EMP was started against PSA failure. During the 3-year treatment with EMP, PSA decreased to the nadir of 0.7 ng/ml and gradually increased to 14 ng/ml. After withdrawal of EMP, PSA decreased to 0.3 ng/ml (97.9% decline) and remained at this level for 4 months. Case 2 was a 61-year-old man who visited our hospital with gross hematuria. Transurethral bladder biopsy and transrectal prostate biopsy were performed. The diagnosis was moderately differentiated adenocarcinoma of the prostate that invaded to the bladder. Computed tomography (CT) showed a lymph node metastasis. He was treated with LH-RHa and BCL. The treatment was changed to EMP after PSA failure. EMP was withdrawn when PSA was 30 ng/ml. Then PSA decreased to less than 0.2 ng/ml (99% decline) and remained at this level for 9 months. We consider that in patients with EMP-resistant progression, EMP withdrawal syndrome should be checked
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| 650 |
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|a Case Reports
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| 650 |
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|a English Abstract
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| 650 |
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|a Journal Article
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| 650 |
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|a Review
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| 650 |
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|a Antineoplastic Agents, Hormonal
|2 NLM
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| 650 |
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7 |
|a Estramustine
|2 NLM
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| 650 |
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7 |
|a 35LT29625A
|2 NLM
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| 700 |
1 |
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|a Tsukamoto, Tetsuro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tohsaka, Akira
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tohma, Tsuguhiro
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Hinyokika kiyo. Acta urologica Japonica
|d 1962
|g 54(2008), 6 vom: 07. Juni, Seite 423-6
|w (DE-627)NLM012631779
|x 0018-1994
|7 nnns
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| 773 |
1 |
8 |
|g volume:54
|g year:2008
|g number:6
|g day:07
|g month:06
|g pages:423-6
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