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01000naa a22002652 4500 |
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231223s2008 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2008.02.013
|2 doi
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|a pubmed24n0603.xml
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|a (DE-627)NLM180845144
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|a (NLM)18620909
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Sánchez-Ramón, Silvia
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Memory B cells in common variable immunodeficiency
|b clinical associations and sex differences
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| 264 |
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1 |
|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 05.09.2008
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|a Date Revised 23.02.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by impaired antibody responses, recurrent infections, inflammatory, autoimmune and malignancy-related conditions. We evaluated the relationship between memory B cell phenotype, sex, age at diagnosis, immunologic and clinical conditions in 105 CVID subjects from one medical center. Reduced numbers of switched memory B cells (cutoff <or=0.55% of B cells) were an independent risk factor of granulomas, autoimmune diseases and splenomegaly (p<0.001). Not previously noted, CVID females had significantly more switched memory cells (p=0.007) than males. Splenectomized subjects did not have fewer IgM memory B cells and these numbers were not related to the development of lung disease, as previously proposed. Lower baseline serum IgG was an independent predictor of pneumonia (p=0.007) and severe infections (p=0.001). We conclude that outcomes in CVID depend on an interplay of factors including sex, numbers of switched memory B cells, and baseline serum IgG and IgA levels
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| 650 |
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Antibodies
|2 NLM
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| 650 |
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|a Immunoglobulin A
|2 NLM
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| 650 |
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|a Immunoglobulin G
|2 NLM
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| 650 |
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|a Pneumococcal Vaccines
|2 NLM
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| 700 |
1 |
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|a Radigan, Lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Joyce E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bard, Susan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cunningham-Rundles, Charlotte
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 128(2008), 3 vom: 01. Sept., Seite 314-21
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:128
|g year:2008
|g number:3
|g day:01
|g month:09
|g pages:314-21
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|u http://dx.doi.org/10.1016/j.clim.2008.02.013
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