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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.05.003
|2 doi
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|a pubmed24n0602.xml
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|a (DE-627)NLM180516280
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|a (NLM)18585960
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Kantele, Anu M
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Distinctive homing profile of pathogen-specific activated lymphocytes in human urinary tract infection
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 05.09.2008
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|a Date Revised 18.08.2008
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In contrast to other mucosal sites, information on migration/homing of lymphocytes activated in the human urinary tract is lacking. The expression of lymphocyte homing receptors (HR) on pathogen-specific antibody-secreting cells (ASC) originating from the urinary tract (patients with pyelonephritis, PN) was compared to that on antigen-specific ASC originating from the intestine (patients with gastroenteritis) or from a parenteral site (tetanus toxoid-immunized volunteers). In the PN group, 61% of ASC expressed the gut HR, alpha(4)beta(7,) 52% the peripheral lymph node HR, L-selectin, and 13% the skin HR, CLA. This homing profile of urinary tract-originating lymphocytes was found to differ from both of the two major vaccination routes, intestinal (less gut-targeting) or parenteral (more gut-targeting, less targeting to parenteral sites). This information on targeting of the immune response may prove useful when developing vaccines against urinary tract infection (UTI)
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Integrins
|2 NLM
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| 650 |
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|a Receptors, Lymphocyte Homing
|2 NLM
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| 650 |
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|a Tetanus Toxoid
|2 NLM
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| 650 |
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|a L-Selectin
|2 NLM
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| 650 |
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|a 126880-86-2
|2 NLM
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| 700 |
1 |
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|a Palkola, Nina V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Arvilommi, Heikki S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kantele, Jussi M
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 128(2008), 3 vom: 31. Sept., Seite 427-34
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:128
|g year:2008
|g number:3
|g day:31
|g month:09
|g pages:427-34
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2008.05.003
|3 Volltext
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|d 128
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