Systemic administration of an Fcgamma-Fc(epsilon)-fusion protein in house dust mite sensitive nonhuman primates
Crosslinking Fc(epsilon)RI and FcgammaRIIB receptors inhibits mast cell and basophil activation, decreasing mediator release. In this study, a fusion protein incorporating human Fcgamma and Fc(epsilon) domains, hGE2, was shown to inhibit degranulation of human mast cells and basophils, and to exhibi...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 128(2008), 3 vom: 15. Sept., Seite 340-8
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| 1. Verfasser: |
Van Scott, Michael R
(VerfasserIn) |
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| Weitere Verfasser: |
Mertsching, Elisabeth,
Negrou, Ella,
Miles, Jeremy,
Stallings, Howard W 3rd,
Graff, Candace,
Kehry, Marilyn R |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2008
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.)
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
Allergens
FCGR2B protein, human
Receptors, IgE
Receptors, IgG
Recombinant Fusion Proteins |
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