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231223s2008 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1021/la800942n
|2 doi
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|a pubmed24n0601.xml
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|a (DE-627)NLM180393448
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|a (NLM)18572891
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Krysmann, M J
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Self-assembly of Peptide nanotubes in an organic solvent
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 08.09.2008
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The self-assembly of a modified fragment of the amyloid beta peptide, based on sequence Abeta(16-20), KLVFF, extended to give AAKLVFF is studied in methanol. Self-assembly into peptide nanotubes is observed, as confirmed by electron microscopy and small-angle X-ray scattering. The secondary structure of the peptide is probed by FTIR and circular dichroism, and UV/visible spectroscopy provides evidence for the important role of aromatic interactions between phenylalanine residues in driving beta-sheet self-assembly. The beta-sheets wrap helically to form the nanotubes, the nanotube wall comprising four wrapped beta-sheets. At higher concentration, the peptide nanotubes form a nematic phase that exhibits spontaneous flow alignment as observed by small-angle neutron scattering
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|a Journal Article
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|a Nanotubes, Peptide
|2 NLM
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|a Solvents
|2 NLM
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| 650 |
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7 |
|a Methanol
|2 NLM
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| 650 |
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7 |
|a Y4S76JWI15
|2 NLM
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| 700 |
1 |
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|a Castelletto, V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a McKendrick, J E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Clifton, L A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a W Hamley, I
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Harris, P J F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a King, S M
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 24(2008), 15 vom: 05. Aug., Seite 8158-62
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
8 |
|g volume:24
|g year:2008
|g number:15
|g day:05
|g month:08
|g pages:8158-62
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/la800942n
|3 Volltext
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