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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1021/la704046f
|2 doi
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|a pubmed24n0601.xml
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|a (DE-627)NLM180214837
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|a (NLM)18553993
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hamasaki, Takeki
|e verfasserin
|4 aut
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|a Kinetic analysis of superoxide anion radical-scavenging and hydroxyl radical-scavenging activities of platinum nanoparticles
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 15.08.2008
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a There are few reports on the physiological effects of metal nanoparticles (nps), especially with respect to their functions as scavengers for superoxide anion radical (O2(.-)) and hydroxyl radical (.OH). We tried to detect the scavenging activity of Pt nps using a hypoxanthine-xanthine oxidase system for O2(.-) and using a Fenton and a UV/H2O2 system for .OH. Electron spin resonance analysis revealed that 2 nm particle size Pt nps have the ability to scavenge O2(.-) and .OH. The calculated rate constant for the O2(.-)-scavenging reaction was 5.03 +/- 0.03 x 10(7) M (-1) s (-1). However, the analysis of the Fenton and UV/H 2O 2 system in the presence of Pt nps suggested that the .OH-scavenging reaction cannot be determined in both systems. Among particle sizes tested from 1 to 5 nm, 1 nm Pt nps showed the highest O2(.-)-scavenging ability. Almost no cytotoxicity was observed even after adherent cells (TIG-1, HeLa, HepG2, WI-38, and MRC-5) were exposed to Pt nps at concentrations as high as 50 mg/L. Pt nps scavenged intrinsically generated reactive oxygen species (ROS) in HeLa cells. Additionally, Pt nps significantly reduced the levels of intracellular O2(.-) generated by UVA irradiation and subsequently protected HeLa cells from ROS damage-induced cell death. These findings suggest that Pt nps may be a new type of antioxidant capable of circumventing the paradoxical effects of conventional antioxidants
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|a Journal Article
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|a Anions
|2 NLM
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|a Superoxides
|2 NLM
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|a 11062-77-4
|2 NLM
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|a Hydroxyl Radical
|2 NLM
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|a 3352-57-6
|2 NLM
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|a Platinum
|2 NLM
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|a 49DFR088MY
|2 NLM
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1 |
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|a Kashiwagi, Taichi
|e verfasserin
|4 aut
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|a Imada, Toshifumi
|e verfasserin
|4 aut
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| 700 |
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|a Nakamichi, Noboru
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Aramaki, Shinsuke
|e verfasserin
|4 aut
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| 700 |
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|a Toh, Kazuko
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Morisawa, Shinkatsu
|e verfasserin
|4 aut
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| 700 |
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|a Shimakoshi, Hisashi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hisaeda, Yoshio
|e verfasserin
|4 aut
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| 700 |
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|a Shirahata, Sanetaka
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 24(2008), 14 vom: 15. Juli, Seite 7354-64
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:24
|g year:2008
|g number:14
|g day:15
|g month:07
|g pages:7354-64
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|u http://dx.doi.org/10.1021/la704046f
|3 Volltext
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