A ChIP-cloning approach linking SIRT1 to transcriptional modificationof DNA targets
The mammalian protein deacetylase SIRT1 (sirtuin1) is widely recognized for its link to calorie restriction and longevity. SIRT1 not only modulates the function of protein targets such as p53 or NFkappaB, but it also affects gene transcription by causing hypoacetylation of associated nucleosomal his...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | BioTechniques. - 1991. - 44(2008), 7 vom: 01. Juni, Seite Pxii-Pxiv
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| 1. Verfasser: |
Torres, German
(VerfasserIn) |
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| Weitere Verfasser: |
Frisella, Patrick D,
Yousuf, Salman J,
Sarwar, Samina,
Baldinger, Lauren,
Zakhary, Sherry M,
Leheste, Joerg R |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2008
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| Zugriff auf das übergeordnete Werk: | BioTechniques
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
NOVA2 protein, human
Nerve Tissue Proteins
Neuro-Oncological Ventral Antigen
RNA-Binding Proteins
SIRT1 protein, human
EC 3.5.1.-
Sirtuin 1
Sirtuins |
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