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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/ern133
|2 doi
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|a pubmed24n1377.xml
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|a (NLM)18515827
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Christian, May
|e verfasserin
|4 aut
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|a Identification of auxins by a chemical genomics approach
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 28.08.2008
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|a Date Revised 16.04.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Thirteen auxenic compounds were discovered in a screen of 10 000 compounds for auxin-like activity in Arabidopsis roots. One of the most potent substances was 2-(4-chloro-2-methylphenoxy)-N-(4-H-1,2,4-triazol-3-yl)acetamide (WH7) which shares similar structure to the known auxenic herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). A selected set of 20 analogues of WH7 was used to provide detailed information about the structure-activity relationship based on their efficacy at inhibiting and stimulating root and shoot growth, respectively, and at induction of gene expression. It was shown that WH7 acts in a genetically defined auxin pathway. These small molecules will extend the arsenal of substances that can be used to define auxin perception site(s) and to dissect subsequent signalling events
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a 2,4-D
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|a Auxin
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|a growth control
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|a sensitivity
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|a structure–activity
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|a Arabidopsis Proteins
|2 NLM
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|a Glycolates
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|a Indoleacetic Acids
|2 NLM
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|a Membrane Transport Proteins
|2 NLM
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|a PIN1 protein, Arabidopsis
|2 NLM
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|a Plant Growth Regulators
|2 NLM
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|a Small Molecule Libraries
|2 NLM
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|a 1-naphthoxyacetic acid
|2 NLM
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| 650 |
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|a 9QI2464POA
|2 NLM
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| 700 |
1 |
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|a Hannah, William B
|e verfasserin
|4 aut
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|a Lüthen, Hartwig
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jones, Alan M
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 59(2008), 10 vom: 28., Seite 2757-67
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|x 1460-2431
|7 nnns
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| 773 |
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|g volume:59
|g year:2008
|g number:10
|g day:28
|g pages:2757-67
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|u http://dx.doi.org/10.1093/jxb/ern133
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