Chemokine-receptor upregulation and disease severity in respiratory syncytial virus infection

Chemokine-receptor upregulation and disease severity in respiratory syncytial virus infection

Respiratory Syncytial Virus (RSV) infection is an important cause of severe infant bronchiolitis, partly due to lower airway inflammation orchestrated by virus-induced chemokine secretion. Chemokine receptors may therefore be therapeutic targets. We investigated RSV-induced chemokine receptor (CCR)...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 128(2008), 1 vom: 01. Juli, Seite 85-93
1. Verfasser: Morrison, Paul T (VerfasserIn)
Weitere Verfasser: Sharland, Mike, Thomas, Lynette H, Manna, Soumendu, Handforth, Jenny, Tibby, Shane, Friedland, Jon S
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't CCR1 protein, human CCR2 protein, human Receptors, CCR1 Receptors, CCR2 Receptors, CCR5
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520 |a Respiratory Syncytial Virus (RSV) infection is an important cause of severe infant bronchiolitis, partly due to lower airway inflammation orchestrated by virus-induced chemokine secretion. Chemokine receptors may therefore be therapeutic targets. We investigated RSV-induced chemokine receptor (CCR) 1, 2 and 5 surface expressions in a cellular model and in infants. RSV infection increased human monocytic CCR1, 2 and 5 expression, as assessed by FACS, via replication-dependent mechanisms. CCR1 and CCR5 levels peaked at 36 h and CCR2 levels at 48 h. Monocytes from infants with RSV-bronchiolitis significantly increased CCR1 expression after ex vivo RSV infection compared to controls. Expression of CCR5 also increased, and correlated with CCR1 expression (r=0.78, p<0.0001). CCR1 upregulation correlated with disease severity markers. Monocyte CCR1 receptors were functionally active as stimulation resulted in calcium influx. CCR1/5 blocking strategies may be useful in decreasing cellular inflammation in RSV infection 
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650 4 |a Research Support, Non-U.S. Gov't 
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700 1 |a Sharland, Mike  |e verfasserin  |4 aut 
700 1 |a Thomas, Lynette H  |e verfasserin  |4 aut 
700 1 |a Manna, Soumendu  |e verfasserin  |4 aut 
700 1 |a Handforth, Jenny  |e verfasserin  |4 aut 
700 1 |a Tibby, Shane  |e verfasserin  |4 aut 
700 1 |a Friedland, Jon S  |e verfasserin  |4 aut 
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