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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1107/S0909049508006584
|2 doi
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|a pubmed24n0597.xml
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|a (DE-627)NLM179011081
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|a (NLM)18421159
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Miyoshi, Toshinobu
|e verfasserin
|4 aut
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|a Development of an X-ray HARP-FEA detector system for high-throughput protein crystallography
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 31.07.2008
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a A new detector system for protein crystallography is now being developed based on an X-ray HARP-FEA (high-gain avalanche rushing amorphous photoconductor-field emitter array), which consists of an amorphous selenium membrane and a matrix field emitter array. The combination of the membrane avalanche effect with a single driven FEA has several advantages over currently available area detectors, including higher sensitivity, higher spatial resolution and a higher frame rate. Preliminary evaluation of the detector has been carried out and its effectiveness has been confirmed. Next, diffraction images were measured with continuous rotation of a protein crystal, and the images were compared with those measured by the existing CCD detector; the system successfully obtained high-spatial-resolution images. Using shutterless measurement, the total measurement time can be reduced significantly, making the method appropriate for high-throughput protein crystallography. The X-ray HARP-FEA detector is an attractive candidate for the next generation of X-ray area detectors
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Proteins
|2 NLM
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|a Igarashi, Noriyuki
|e verfasserin
|4 aut
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|a Matsugaki, Naohiro
|e verfasserin
|4 aut
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1 |
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|a Yamada, Yusuke
|e verfasserin
|4 aut
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|a Hirano, Keiichi
|e verfasserin
|4 aut
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|a Hyodo, Kazuyuki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tanioka, Kenkichi
|e verfasserin
|4 aut
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1 |
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|a Egami, Norifumi
|e verfasserin
|4 aut
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1 |
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|a Namba, Masakazu
|e verfasserin
|4 aut
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1 |
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|a Kubota, Misao
|e verfasserin
|4 aut
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|a Kawai, Teruo
|e verfasserin
|4 aut
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| 700 |
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|a Wakatsuki, Soichi
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of synchrotron radiation
|d 1994
|g 15(2008), Pt 3 vom: 07. Mai, Seite 281-4
|w (DE-627)NLM09824129X
|x 1600-5775
|7 nnns
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| 773 |
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|g volume:15
|g year:2008
|g number:Pt 3
|g day:07
|g month:05
|g pages:281-4
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|u http://dx.doi.org/10.1107/S0909049508006584
|3 Volltext
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|d 15
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|e Pt 3
|b 07
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|h 281-4
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