The structures of both native and S139A holo-HCV NS3/4A protease domain were solved to high resolution. Subsequently, structures were determined for a series of ketoamide inhibitors in complex with the protease. The changes in the inhibitor potency were correlated with changes in the buried surface...
Bibliographische Detailangaben
| Veröffentlicht in: | Journal of synchrotron radiation. - 1994. - 15(2008), Pt 3 vom: 07. Mai, Seite 204-7
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| 1. Verfasser: |
Madison, Vincent
(VerfasserIn) |
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| Weitere Verfasser: |
Prongay, Andrew J,
Guo, Zhuyan,
Yao, Nanhua,
Pichardo, John,
Fischmann, Thierry,
Strickland, Corey,
Myers, Joseph Jr,
Weber, Patricia C,
Beyer, Brian M,
Ingram, Richard,
Hong, Zhi,
Prosise, Winifred W,
Ramanathan, Lata,
Taremi, S Shane,
Yarosh-Tomaine, Taisa,
Zhang, Rumin,
Senior, Mary,
Yang, Rong Sheng,
Malcolm, Bruce,
Arasappan, Ashok,
Bennett, Frank,
Bogen, Stephane L,
Chen, Kevin,
Jao, Edwin,
Liu, Yi Tsung,
Lovey, Raymond G,
Saksena, Anil K,
Venkatraman, Srikanth,
Girijavallabhan, Viyyoor,
Njoroge, F George |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2008
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| Zugriff auf das übergeordnete Werk: | Journal of synchrotron radiation
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| Schlagworte: | Journal Article
NS3 protein, hepatitis C virus
NS4A protein, flavivirus
Protease Inhibitors
Viral Nonstructural Proteins
N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide
89BT58KELH
Proline
9DLQ4CIU6V |
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