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|a jpn
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| 100 |
1 |
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|a Kanno, Hitomi
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Histopathological characteristics of radical prostatectomy specimen and long-term PSA changes in men with PSA levels of 4.0 ng/ml or less
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|2 rdacarrier
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|a Date Completed 13.05.2008
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|a Date Revised 16.04.2008
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|a published: Print
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|a Citation Status MEDLINE
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|a Out of 132 prostate cancer (Pca) patients who underwent radical prostatectomy 31 (mean age 65 +/- 5 years) had prostate specific antigen (PSA) levels of 4.0 ng/ml or less (low PSA group). The average PSA level was 3.3 +/- 0.5 ng/ml in the low PSA group and 8.5 +/- 5.5 ng/ml in patients with a higher PSA (high PSA group). The pT2 ratio of the radical prostatectomy specimens was 74% (23/31) in the low PSA group and 55% (55/101) in the high PSA group, pT3a was 16% (5/31) and 31% (31/101), pT3b was 10% (3/31) and 10% (10/101), pN1 was 0% and 5% (5/101), respectively. The digital rectal examination (DRE) gave a positive result significantly (p = 0.026) less frequently in the low PSA group (6/31 : 20%), than in the high PSA group (44/101 : 44%). However all three pT3b patients with a low PSA were positive in DRE. This suggests the importance of DRE to detect significant Pca with PSA < or = 4.0. PSA was measured at least three times for more than one year in 19 of the 31 patients with a low PSA level before diagnosis. In 14 of these 19 cases (74%), PSA velocity was more than 0.5 ng/ml/ year and PSA doubling time was less than 4 years. Some patients with significant Pca can not be detected with a PSA cutoff level at 4.0 ng/ml. We recommend that individuals have their own PSA levels, and that long-term changes of PSA are sometimes very important to detect cases of Pca with lower PSA
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|a English Abstract
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|a Journal Article
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|a Review
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|a Prostate-Specific Antigen
|2 NLM
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| 700 |
1 |
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| 700 |
1 |
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|a Izumi, Koji
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|4 aut
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| 700 |
1 |
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|a Hasumi, Hisashi
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| 700 |
1 |
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|a Osada, Yutaka
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| 700 |
1 |
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|a Ohta, Junichi
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|4 aut
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| 700 |
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|a Tuchiya, Futoshi
|e verfasserin
|4 aut
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| 700 |
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|a Kuwao, Sadahito
|e verfasserin
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| 773 |
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|i Enthalten in
|t Hinyokika kiyo. Acta urologica Japonica
|d 1962
|g 54(2008), 3 vom: 15. März, Seite 207-15
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|x 0018-1994
|7 nnas
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|g volume:54
|g year:2008
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|g day:15
|g month:03
|g pages:207-15
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