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DE-627 |
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20231223152637.0 |
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cr uuu---uuuuu |
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231223s2008 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2008.01.017
|2 doi
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|a pubmed24n0596.xml
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|a (DE-627)NLM178760757
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|a (NLM)18394967
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Gu, Xue-Jiang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Association of the interleukin (IL)-16 gene polymorphisms with Graves' disease
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| 264 |
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1 |
|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 07.07.2008
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|a Date Revised 16.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Interleukin (IL)-16 was one of the cytokines with the function of T helper cell recruitment, whose expression in the thyrocyte and orbital fibroblast of Graves' disease (GD) patients was increased. Recently association of IL-16 gene polymorphisms with autoimmune diseases had been reported. However, there was little known about the impact of IL-16 gene polymorphisms on GD. In this study, we performed a case-control association study of three tagSNPs (rs4778889-rs1131445-rs4778641) within the IL-16 gene on 258 patients with GD and 208 healthy subjects in the Chinese population. Our data showed that common IL-16 variants were associated with GD (P=0.013-0.0186) and Graves' disease associated ophthalmopathy (GO) (P=0.0033-0.041). A novel protective haplotype containing the three tagSNPs (C-T-C) was observed in association with GO (P=0.013). In conclusion, IL-16 gene was significantly associated with susceptibility to Graves' disease and Graves' disease associated ophthalmopathy in the Chinese population
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Interleukin-16
|2 NLM
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| 700 |
1 |
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|a Cui, Bin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Ze-Fei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Hao-Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xiao-Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Shu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ning, Guang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Yong-Ju
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 127(2008), 3 vom: 15. Juni, Seite 298-302
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:127
|g year:2008
|g number:3
|g day:15
|g month:06
|g pages:298-302
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2008.01.017
|3 Volltext
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|a AR
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|d 127
|j 2008
|e 3
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|h 298-302
|