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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.2227
|2 doi
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|a pubmed24n0596.xml
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|a eng
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| 100 |
1 |
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|a Steyn, Pieter S
|e verfasserin
|4 aut
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|a Synthesis, complete 1H and 13C NMR assignment and crystal structure of novel epoxide derivatives of cytochalasin B
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 05.08.2008
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a Copyright (c) 2008 John Wiley & Sons, Ltd.
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|a Five novel epoxide derivatives of cytochalasin B were synthesized. Reaction of cytochalasin B with t-BHP and BuLi led to selective epoxidation of the C-21/22 double bond to give a single monoepoxide, while reaction with m-CPBA yielded two diepoxides. Reaction of the monoepoxide with m-CPBA yielded two triepoxides. The relative configurations of the epoxides were elucidated by analogy with the natural product by means of spectroscopic methods; full assignment of NMR signals was achieved, and the absolute configuration was confirmed by X-ray crystallography
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|a Journal Article
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|a Carbon Isotopes
|2 NLM
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| 650 |
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|a Epoxy Compounds
|2 NLM
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| 650 |
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|a Protons
|2 NLM
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|a Cytochalasin B
|2 NLM
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|a 3CHI920QS7
|2 NLM
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1 |
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|a Breytenbach, Jaco C
|e verfasserin
|4 aut
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|a Botha, Jeanne H
|e verfasserin
|4 aut
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1 |
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|a Fernandes, Manuel A
|e verfasserin
|4 aut
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|a Wessels, Philippus L
|e verfasserin
|4 aut
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 46(2008), 7 vom: 05. Juli, Seite 650-9
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|x 1097-458X
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|g volume:46
|g year:2008
|g number:7
|g day:05
|g month:07
|g pages:650-9
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|u http://dx.doi.org/10.1002/mrc.2227
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