Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice
A deficit in IL-4 production has been previously reported in both diabetic human patients and non-obese diabetic (NOD) mice. In addition, re-introducing IL-4 into NOD mice systemically, or as a transgene, led to a beneficial outcome in most studies. Here, we show that prediabetic, 12-week old female...
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Bibliographische Detailangaben
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 127(2008), 2 vom: 30. Mai, Seite 176-87
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| 1. Verfasser: |
Creusot, Rémi J
(VerfasserIn) |
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| Weitere Verfasser: |
Yaghoubi, Shahriar S,
Kodama, Keiichi,
Dang, Demi N,
Dang, Vu H,
Breckpot, Karine,
Thielemans, Kris,
Gambhir, Sanjiv S,
Fathman, C Garrison |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2008
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.)
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| Schlagworte: | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Blood Glucose
Histocompatibility Antigens
Interleukin-4
207137-56-2
RNA
63231-63-0 |
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