TGFbeta1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function
TGFbeta1 is considered to be required for peripheral maintenance of CD4(+)CD25(+)FOXP3(+) T(reg) cells. However, we demonstrate no reduction in the percentage of such T cells in the spleens and thymi of Tgfb1(-/-) mice. Although putative T(reg) cells, characterized as CD4(+)CD25(+)FOXP3(+)CD62L(+) T...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 127(2008), 2 vom: 15. Mai, Seite 206-13
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| 1. Verfasser: |
Bommireddy, Ramireddy
(VerfasserIn) |
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| Weitere Verfasser: |
Babcock, George F,
Singh, Ram R,
Doetschman, Thomas |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2008
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.)
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| Schlagworte: | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
CD69 antigen
Forkhead Transcription Factors
Foxp3 protein, mouse
Lectins, C-Type
Transforming Growth Factor beta1
mehr...
L-Selectin
126880-86-2 |
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