Analysis of similarity/dissimilarity of DNA sequences based on a class of 2D graphical representation
(c) 2008 Wiley Periodicals, Inc. J Comput Chem, 2008.
| Veröffentlicht in: | Journal of computational chemistry. - 1984. - 29(2008), 10 vom: 30. Juli, Seite 1632-9 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2008
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| Zugriff auf das übergeordnete Werk: | Journal of computational chemistry |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Globins 9004-22-2 DNA 9007-49-2 |
| Zusammenfassung: | (c) 2008 Wiley Periodicals, Inc. J Comput Chem, 2008. On the basis of a class of 2D graphical representations of DNA sequences, sensitivity analysis has been performed, showing the high-capability of the proposed representations to take into account small modifications of the DNA sequences. And sensitivity analysis also indicates that the absolute differences of the leading eigenvalues of the L/L matrices associated with DNA increase with the increase of the number of the base mutations. Besides, we conclude that the similarity analysis method based on the correlation angles can better eliminate the effects of the lengths of DNA sequences if compared with the method using the Euclidean distances. As application, the examination of similarities/dissimilarities among the coding sequences of the first exon of beta-globin gene of different species has been performed by our method, and the reasonable results verify the validity of our method |
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| Beschreibung: | Date Completed 07.08.2008 Date Revised 02.06.2008 published: Print Citation Status MEDLINE |
| ISSN: | 1096-987X |
| DOI: | 10.1002/jcc.20922 |