The importance of cognitive phenotypes in experimental modeling of animal anxiety and depression
Cognitive dysfunctions are commonly seen in many stress-related disorders, including anxiety and depression-the world's most common neuropsychiatric illnesses. Various genetic, pharmacological, and behavioral animal models have long been used to establish animal anxiety-like and depression-like...
| Publié dans: | Neural plasticity. - 1998. - 2007(2007) vom: 20., Seite 52087 |
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| Auteur principal: | |
| Autres auteurs: | |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2007
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| Accès à la collection: | Neural plasticity |
| Sujets: | Journal Article Research Support, N.I.H., Intramural Review |
| Résumé: | Cognitive dysfunctions are commonly seen in many stress-related disorders, including anxiety and depression-the world's most common neuropsychiatric illnesses. Various genetic, pharmacological, and behavioral animal models have long been used to establish animal anxiety-like and depression-like phenotypes, as well as to assess their memory, learning, and other cognitive functions. Mounting clinical and animal evidences strongly supports the notion that disturbed cognitions represent an important pathogenetic factor in anxiety and depression, and may also play a role in integrating the two disorders within a common stress-precipitated developmental pathway. This paper evaluates why and how the assessment of cognitive and emotional domains may improve our understanding of animal behaviors via different high-throughput tests and enable a better translation of animal phenotypes into human brain disorders |
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| Description: | Date Completed 27.03.2008 Date Revised 20.10.2021 published: Print Citation Status MEDLINE |
| ISSN: | 1687-5443 |
| DOI: | 10.1155/2007/52087 |