Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

The effects of galectin-9 on a mouse collagen-induced arthritis (CIA) model were assessed to clarify whether galectin-9 suppresses CIA by regulating T cell immune responses. Galectin-9 suppressed CIA in a dose-dependent manner, and such suppression was observed even when treatment was started on 7 d...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 127(2008), 1 vom: 15. Apr., Seite 78-88
1. Verfasser: Seki, Masako (VerfasserIn)
Weitere Verfasser: Oomizu, Souichi, Sakata, Ken-Mei, Sakata, Atsuko, Arikawa, Tomohiro, Watanabe, Kota, Ito, Kanako, Takeshita, Keisuke, Niki, Toshiro, Saita, Naoki, Nishi, Nozomu, Yamauchi, Akira, Katoh, Shigeki, Matsukawa, Akihiro, Kuchroo, Vijay, Hirashima, Mitsuomi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Autoantigens Galectins Interleukin-17 galectin 9, mouse Interleukin-12 187348-17-0 Interferon-gamma 82115-62-6 mehr... Collagen 9007-34-5