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tu |
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231223s2007 xx ||||| 00| ||chi c |
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|a pubmed25n0592.xml
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|a (DE-627)NLM177690879
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|a (NLM)18282420
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Xin, Ying
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The changes of serum interferon-inducible protein-10 levels in children with type 1 diabetes mellitus
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 22.12.2010
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| 500 |
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|a Date Revised 07.06.2016
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: Type 1 diabetes mellitus (T1DM) has been recognized as a T-cell mediated autoimmune disease, the migration of immune effector cells from the bloodstream into the pancreatic islet may be a crucial step in the pathogenesis of T1DM. However, a clinically applicable method for measuring pancreatic beta-cell specific T-cell function in cases of T1DM has not been established. Interferon-inducible protein-10 (IP-10) is a chemokine that promotes the migration of activated T cells. The aim of this study was to investigate the role of IP-10 in the pathogenesis of childhood T1DM
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| 520 |
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|a METHODS: Serum IP-10 levels were measured by ELISA in 50 children with T1DM and 30 healthy children, and the levels of autoantibodies [glutamic acid decarboxylase (GAD), isle tcell antibody (ICA), insulin autoantibody (IAA) and tyrosine phosphatase (IA-2)] in diabetic children were measured as well. Comparisons were made among groups divided by autoantibody condition and disease period
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| 520 |
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|a RESULTS: The serum levels of IP-10 in patients with T1DM [(367 +/- 130) ng/L] were significantly higher than those in controls [(133 +/- 43) ng/L] (t = 9.49, P < 0.01). IP-10 levels in autoantibody positive [(385 +/- 147) ng/L] and negative diabetic children [(311 +/- 101) ng/L] were both higher than those in controls, but the difference was not significant. The serum levels of IP-10 among diabetic children who were positive for 1, 2 or 3 kinds of autoantibody did not show significant difference (F = 1.46, P > 0.05). IP-10 levels in newly diagnosed patients were much higher than those with disease period longer than 2 years (t = 4.30, P < 0.01), although both of them were higher than those in controls
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| 520 |
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|a CONCLUSION: The serum levels of IP-10 in children with T1DM were higher than those in controls, but they were not affected by either the presence of autoantibody or the number of positive autoantibodies. IP-10 levels decreased gradually with disease period prolonged
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| 650 |
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|a English Abstract
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| 650 |
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4 |
|a Journal Article
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| 650 |
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7 |
|a Chemokine CXCL10
|2 NLM
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| 700 |
1 |
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|a Zhao, Yong-qiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Yong-xin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Li-hua
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 45(2007), 11 vom: 15. Nov., Seite 853-5
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
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|g volume:45
|g year:2007
|g number:11
|g day:15
|g month:11
|g pages:853-5
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|d 45
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