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231223s2008 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2008.01.005
|2 doi
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|a pubmed24n0592.xml
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|a (DE-627)NLM17767539X
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|a (NLM)18280792
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Tian, Chaorui
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Induction of transplantation tolerance by combining non-myeloablative conditioning with delivery of alloantigen by T cells
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| 264 |
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1 |
|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 24.06.2008
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a CommentIn: Clin Immunol. 2008 May;127(2):121-2. - PMID 18405862
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|a Citation Status MEDLINE
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|a The observation that bone marrow derived hematopoietic cells are potent inducers of tolerance has generated interest in trying to establish transplantation tolerance by inducing a state of hematopoietic chimerism through allogeneic bone marrow transplantation. However, this approach is associated with serious complications that limit its utility for tolerance induction. Here we describe the development of a novel approach that allows for tolerance induction without the need for an allogeneic bone marrow transplant by combining non-myeloablative host conditioning with delivery of donor alloantigen by adoptively transferred T cells. CBA/Ca mice were administered 2.5 Gy whole body irradiation (WBI). The following day the mice received K(b) disparate T cells from MHC class I transgenic CBK donor mice, as well as rapamycin on days 0-13 and anti-CD40L monoclonal antibody on days 0-5, 8, 11 and 14 relative to T cell transfer. Mice treated using this approach were rendered specifically tolerant to CBK skin allografts through a mechanism involving central and peripheral deletion of alloreactive T cells. These data suggest robust tolerance can be established without the need for bone marrow transplantation using clinically relevant non-myeloablative conditioning combined with antigen delivery by T cells
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| 650 |
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4 |
|a Journal Article
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Immunosuppressive Agents
|2 NLM
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| 650 |
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7 |
|a Isoantigens
|2 NLM
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| 650 |
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7 |
|a Sirolimus
|2 NLM
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| 650 |
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7 |
|a W36ZG6FT64
|2 NLM
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| 700 |
1 |
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|a Yuan, Xueli
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bagley, Jessamyn
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Blazar, Bruce R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sayegh, Mohamed H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Iacomini, John
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 127(2008), 2 vom: 01. Mai, Seite 130-7
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:127
|g year:2008
|g number:2
|g day:01
|g month:05
|g pages:130-7
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2008.01.005
|3 Volltext
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