Silencing of endogenous IL-10 in human dendritic cells leads to the generation of an improved CTL response against human melanoma associated antigenic epitope, MART-1 27-35

Silencing of endogenous IL-10 in human dendritic cells leads to the generation of an improved CTL response against human melanoma associated antigenic epitope, MART-1 27-35

Dendritic cells (DC) present antigenic epitopes to and activate T cells. They also polarize the ensuing T cell response to Th1 or Th2 type response, depending on their cytokine production profile. For example, IL-12 producing DC generate Th1 type T cell response whereas IL-10 producing DC is usually...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 126(2008), 3 vom: 01. März, Seite 251-9
1. Verfasser: Chhabra, Arvind (VerfasserIn)
Weitere Verfasser: Chakraborty, Nitya G, Mukherji, Bijay
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Epitopes MART-1-Melan-A(27-35) epitope Neoplasm Proteins RNA, Small Interfering Interleukin-10 130068-27-8 Green Fluorescent Proteins 147336-22-9 mehr... Interleukin-12 187348-17-0
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