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231223s2008 xx |||||o 00| ||eng c |
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|a 10.1021/la702580j
|2 doi
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|a pubmed24n0591.xml
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|a (DE-627)NLM177259140
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|a (NLM)18237203
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Angelico, Ruggero
|e verfasserin
|4 aut
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| 245 |
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|a Catanionic systems from conversion of nucleotides into nucleo-lipids
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|c 2008
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 14.05.2008
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|a Date Revised 01.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a This article focuses on reactions performed in nanostructured environments where the pair of complementary nucleotides, 5'-AMP and 5'-UMP, are converted into their amphiphilic derivatives. The synthesis is carried out by using the hydrophobic reactant dodecyl epoxide (DE) dispersed in a micellar solution based on the cationic surfactant cetyltrimethylammoniumbromide (CTAB). Novel nucleo-lipids monomers and CTAB molecules give rise to the spontaneous self-assembly of catanionic supramolecular structures in water, showing typical Maltese crosses in optical microscopy. In the final colloidal suspensions, mono- and dichained derivatives have been identified in the system incubated with 5'-UMP through LC-QqTOF-MS analysis, whereas only mono-alkylated adducts are found in the analogue reaction with 5'-AMP. A new di-alkylated 5'-UMP adduct is obtained from the 1:1 mixture of both complementary nucleotides, in addition to the nucleo-lipids found in separate systems. Time-resolved DLS measurements reveal very different kinetic processes for aggregates' formation when 5'-UMP, 5'-AMP, or their equimolar combination are used in the reaction mixture. This system as a whole represents a potential experimental model where the effect of both intermolecular interactions and self-association processes can be investigated by tuning the type of nucleobases in the reaction mixtures
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Cations
|2 NLM
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|a Cetrimonium Compounds
|2 NLM
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|a Colloids
|2 NLM
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|a Epoxy Compounds
|2 NLM
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|a Lipids
|2 NLM
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|a Macromolecular Substances
|2 NLM
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|a Micelles
|2 NLM
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|a Nucleotides
|2 NLM
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|a Surface-Active Agents
|2 NLM
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|a Water
|2 NLM
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|a 059QF0KO0R
|2 NLM
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|a Cetrimonium
|2 NLM
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| 650 |
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|a Z7FF1XKL7A
|2 NLM
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| 700 |
1 |
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|a Ceglie, Andrea
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cuomo, Francesca
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cardellicchio, Cosimo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mascolo, Giuseppe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Colafemmina, Giuseppe
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 24(2008), 6 vom: 18. März, Seite 2348-55
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:24
|g year:2008
|g number:6
|g day:18
|g month:03
|g pages:2348-55
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|u http://dx.doi.org/10.1021/la702580j
|3 Volltext
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