On the formation of discoidal versus threadlike micelles in dilute aqueous surfactant/lipid systems
In a recent study, we showed that the surfactant 1,2-distearoyl-sn-glycero-3-phosphatidylethanolamine-N-[methoxy(polyethylene glycol)-2000 (DSPE-PEG2000) induced mixed micelles of either threadlike or discoidal shape when mixed with different types of lipids. In this study, we have exchanged the PEG...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1991. - 24(2008), 5 vom: 04. März, Seite 1731-9 |
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| Weitere Verfasser: | , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2008
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Lipids Micelles Phosphatidylethanolamines Surface-Active Agents Water 059QF0KO0R 1,2-distearoylphosphatidylethanolamine 1G4B5265CQ mehr... |
| Zusammenfassung: | In a recent study, we showed that the surfactant 1,2-distearoyl-sn-glycero-3-phosphatidylethanolamine-N-[methoxy(polyethylene glycol)-2000 (DSPE-PEG2000) induced mixed micelles of either threadlike or discoidal shape when mixed with different types of lipids. In this study, we have exchanged the PEG-lipid for the more conventional surfactants octaethylene glycol monododecyl ether (C12E8), hexadecyltrimethylammonium bromide (CTAB), and sodium dodecyl sulfate (SDS). Cryo-TEM investigations show that also these surfactants are able to induce the formation of long-lived discoidal micelles. Generally, the preference for either discoidal or threadlike micelles can be tuned by the choice of lipids and environmental conditions in much the same way as observed for the lipid/PEG-lipid system. Our investigation showed, furthermore, that the choice of surfactant may influence the type of mixed micelles formed. It is argued that the formation of discoidal rather than threadlike micelles may be rationalized as an effect of increasing bending rigidity. Our detailed theoretical model calculations show that the bending rigidity becomes significantly raised for aggregates formed by an ionic rather than a nonionic surfactant |
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| Beschreibung: | Date Completed 27.05.2008 Date Revised 01.12.2018 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 0743-7463 |
| DOI: | 10.1021/la702637h |