Maintaining monodispersity in a microbubble population formed by flow-focusing

The dynamic processes impacting the size distributions of lipid-encapsulated microbubbles formed by flow-focusing were observed by video optical microscopy. Parameters studied included the filling gas, gas saturating the surrounding solution, and microbubble size (initial size 2-12 microm) to simula...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 24(2008), 5 vom: 04. März, Seite 1745-9
1. Verfasser: Talu, Esra (VerfasserIn)
Weitere Verfasser: Hettiarachchi, Kanaka, Powell, Robert L, Lee, Abraham P, Dayton, Paul A, Longo, Marjorie L
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Nitrogen N762921K75
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520 |a The dynamic processes impacting the size distributions of lipid-encapsulated microbubbles formed by flow-focusing were observed by video optical microscopy. Parameters studied included the filling gas, gas saturating the surrounding solution, and microbubble size (initial size 2-12 microm) to simulate typical laboratory conditions. Typically, dissolution or growth, followed by Ostwald ripening at a collection cover glass, were observed and quantified. However, in the case of small nitrogen-filled microbubbles surrounded by an air-saturated solution, Ostwald ripening was avoided for at least 9 h. These bubbles had a final size distribution of 1.5 +/- 0.1 microm. This work suggests that lipid-encapsulated microbubbles formed by flow-focusing should be given sufficient time to reach a terminal size before coming into contact with each other. These long-lived mondisperse microbubbles should be of interest in ultrasound contrast agents, microfabrication, food, and research applications 
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650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Research Support, U.S. Gov't, Non-P.H.S. 
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700 1 |a Hettiarachchi, Kanaka  |e verfasserin  |4 aut 
700 1 |a Powell, Robert L  |e verfasserin  |4 aut 
700 1 |a Lee, Abraham P  |e verfasserin  |4 aut 
700 1 |a Dayton, Paul A  |e verfasserin  |4 aut 
700 1 |a Longo, Marjorie L  |e verfasserin  |4 aut 
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