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01000naa a22002652 4500 |
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NLM176936386 |
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DE-627 |
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20231223145128.0 |
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tu |
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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed24n0590.xml
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|a (DE-627)NLM176936386
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|a (NLM)18203522
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Ogushi, Tetsuo
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Effect of Chinese herbal medicine on overactive bladder
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| 264 |
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1 |
|c 2007
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 06.03.2008
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|a Date Revised 10.12.2019
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|a published: Print
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|a Citation Status MEDLINE
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|a Gosha-jinki-gan (GJG), a traditional Chinese medicine, is known to be potentially effective for urinary disturbance. For the clinical evaluation of Gosha-jinki-gan, we administered GJG for 6 weeks to elderly male patients with overactive bladder (OAB) and assessed its efficacy and tolerability. In this study, 30 male patients with over 6 months of OAB symptoms had received 2.5 g GJG mixture x 3/day. After 6 weeks of treatment, the efficacy, safety, and tolerability were assessed. We evaluated International Prostate Symptom Score (I-PSS), Overactive Bladder Symptom Score (OABSS), quality of life (QOL), maximal urinary flow rate (Qmax), average urinary flow rate (Qave), incidence of urinary incontinence, and post-void residual before and after treatment. We observed significant improvements in I-PSS (15.2 +/- 1.0 vs. 12.0 +/- 0.9, p < 0.0001), OABSS (7.5 +/- 0.6 vs. 4.9 +/- 0.5, p < 0.0001), and QOL score (4.4 +/- 1.0 vs. 3.3 +/- 1.1, p < 0.0001, Wilcoxon rank sum test). GJG was significantly effective in improving urgency, micturition frequency, nocturia, and urinary incontinence (p < 0.05). However, Qmax, Qave, and post void residual did not significantly change. Mild adverse effects were observed in 3 cases. The symptoms were diarrhea, nausea, and urinary frequency. These data suggest that Gosha-jinki-gan may be a new potential therapeutic agent for OAB without deterioration of voiding function in men with benign prostatic obstruction (BPO)
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| 650 |
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|a Evaluation Study
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|a Journal Article
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| 650 |
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|a Drugs, Chinese Herbal
|2 NLM
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| 650 |
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7 |
|a gosha-jinki-gan
|2 NLM
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| 700 |
1 |
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|a Takahashi, Satoru
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Hinyokika kiyo. Acta urologica Japonica
|d 1962
|g 53(2007), 12 vom: 10. Dez., Seite 857-62
|w (DE-627)NLM012631779
|x 0018-1994
|7 nnns
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| 773 |
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|g volume:53
|g year:2007
|g number:12
|g day:10
|g month:12
|g pages:857-62
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|d 53
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|h 857-62
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