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DE-627 |
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20250209023913.0 |
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231223s2008 xx ||||| 00| ||chi c |
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|a pubmed25n0590.xml
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|a (DE-627)NLM176897003
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|a (NLM)18199397
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Chen, Zhi-bin
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Study on the relationship between the expression of SOCS-1/3 in the peripheral blood mononuclear cells in patients with multiple organ dysfunction syndrome and their prognosis
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| 264 |
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1 |
|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 05.01.2010
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| 500 |
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|a Date Revised 24.11.2016
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To observe the mRNA and protein expression of suppressor of cytokines signaling protein 1/3 (SOCS-1/3) in the peripheral blood mononuclear cells (PBMCs) in patients with multiple organ dysfunction syndrome (MODS), and to explore the relationship between the SOCS expression and the patients' prognosis
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| 520 |
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|a METHODS: Peripheral blood specimens of 32 patients with MODS and 24 healthy volunteers (controls) were collected and the PBMCs were isolated by centrifugation and Ficoll-Hypaque sedimentation. The mRNA of SOCS-1/3 was determined by reverse transcription-polymerase chain reaction (RT-PCR). And the protein content of SOCS-1/3 was determined by Western blotting. The relationship between the SOCS expression and the patients' prognosis was analyzed
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| 520 |
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|a RESULTS: There was no significant difference in the SOCS-1 mRNA expression between control group and MODS group (0.526+/-0.044 vs. 0.466+/-0.047, P>0.05). The SOCS-1 expression of MODS group was significantly higher than that of control group (0.814+/-0.045 vs. 0.479+/-0.021, P<0.05). In the MODS group, the SOCS-1 mRNA expression and protein content of dead patients were significantly lower than those of survived patients (mRNA 0.487+/-0.032 vs. 0.532+/-0.028, protein 0.787+/-0. 029 vs. 0.838+/-0.040, both P<0.05). There was significant negative correlation between the SOCS-1 mRNA expression and the MODS score (r1=-0.731,P<0.01). There was also significant negative correlation between the SOCS-1 content and the MODS score (r2=-0.526,P<0.01). The SOCS-3 mRNA expression of MODS group was higher than that of control group (0.993+/-0.415 vs. 0.461+/-0.046, P<0.05). The SOCS-3 content in the PBMCs of MODS groups was significant higher than that of control group (0.458+/-0.033 vs. 0.403+/-0. 024, P<0.05). In the MODS group, the SOCS-3 mRNA expression and protein content of dead patients were significant higher than those of survived patients (mRNA 1. 245+/-0.408 vs. 0.805+/-0.326, protein 0.486+/-0.021 vs. 0.425+/-0.016, both P<0.05). There was positive correlation between the SOCS-3 mRNA expression and the MODS score but the correlation was not significant (r=0. 468, P>0.05). And there was significant positive correlation between the SOCS-3 content and the MODS score (r=0.783, P<0.01)
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| 520 |
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|a CONCLUSION: SOCS-1 may protect the tissue from further damage while SOCS-3 may cause tissue damage indirectly. The detection of SOCS-1/3 may help to predict the prognosis of MODS
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| 650 |
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4 |
|a Journal Article
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| 650 |
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7 |
|a RNA, Messenger
|2 NLM
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| 650 |
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7 |
|a SOCS1 protein, human
|2 NLM
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| 650 |
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7 |
|a SOCS3 protein, human
|2 NLM
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| 650 |
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7 |
|a Suppressor of Cytokine Signaling 1 Protein
|2 NLM
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| 650 |
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7 |
|a Suppressor of Cytokine Signaling 3 Protein
|2 NLM
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| 650 |
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7 |
|a Suppressor of Cytokine Signaling Proteins
|2 NLM
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| 700 |
1 |
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|a Liang, Yan-bing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Hao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Xian-shou
|e verfasserin
|4 aut
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| 700 |
1 |
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|a He, Dong-hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Zhong-fu
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 20(2008), 1 vom: 17. Jan., Seite 29-33
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:20
|g year:2008
|g number:1
|g day:17
|g month:01
|g pages:29-33
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 20
|j 2008
|e 1
|b 17
|c 01
|h 29-33
|