A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene

Immunodeficient NOD-scid mice bearing a targeted mutation in the IL2 receptor common gamma chain (Il2rgamma(null)) readily engraft with human stem cells. Here we analyzed human peripheral blood mononuclear cells (PBMC) for their ability to engraft NOD-scid Il2rgamma(null) mice and established engraf...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 126(2008), 3 vom: 12. März, Seite 303-14
1. Verfasser: King, Marie (VerfasserIn)
Weitere Verfasser: Pearson, Todd, Shultz, Leonard D, Leif, Jean, Bottino, Rita, Trucco, Massimo, Atkinson, Mark A, Wasserfall, Clive, Herold, Kevan C, Woodland, Robert T, Schmidt, Madelyn R, Woda, Bruce A, Thompson, Michael J, Rossini, Aldo A, Greiner, Dale L
Format: Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Interleukin Receptor Common gamma Subunit