A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE

A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE

We previously reported that some systemic lupus erythematosus (SLE) patients have a population of circulating memory B cells with >2-fold higher levels of CD19. We show here that the presence of CD19(hi) B cells correlates with long-term adverse outcomes. These B cells do not appear anergic, as t...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 126(2008), 2 vom: 09. Feb., Seite 189-201
1. Verfasser: Nicholas, Matilda W (VerfasserIn)
Weitere Verfasser: Dooley, Mary Anne, Hogan, Susan L, Anolik, Jennifer, Looney, John, Sanz, Ingnacio, Clarke, Stephen H
Format: Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Antibodies, Monoclonal Antibodies, Monoclonal, Murine-Derived Antigens, CD19 Autoantigens CXCL9 protein, human CXCR3 protein, human Chemokine CXCL9 Immunologic Factors mehr... Receptors, CXCR3 Ribonucleoproteins, Small Nuclear snRNP Core Proteins Rituximab 4F4X42SYQ6