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|a pubmed24n0585.xml
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|a (DE-627)NLM175415668
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|a (NLM)18044811
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Hakkarainen, Birgit
|e verfasserin
|4 aut
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|a NMR study of hydroxy protons of di- and trimannosides, substructures of Man-9
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 05.02.2008
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|a Date Revised 03.11.2009
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|a published: Print
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|a Citation Status MEDLINE
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|a Copyright (c) 2007 John Wiley & Sons, Ltd.
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|a The chemical shifts, temperature coefficients and inter-residual rotating-frame Overhauser effect (ROE)s for the hydroxy protons of some alpha-(1,2)-, alpha-(1,3)- and alpha-(1,6)-linked di- and trimannosides have been measured for samples in 85% H2O/15% acetone-d6 solution. These mannosides, Manalpha(1-->2)ManalphaOMe (1) Manalpha(1-->3)ManalphaOMe (2), Manalpha(1-->6)ManalphaOMe (3), Manalpha(1-->2)Manalpha(1-->2)ManalphaOMe (4), Manalpha(1-->2)Manalpha(1-->3)ManalphaOMe (5), Manalpha(1-->2)Manalpha(1-->6)ManalphaOMe (6) and Manalpha(1-->3)[Manalpha1-->6]ManalphaOMe (7), are substructures of the N-glycan Man-9. The NMR data show that the hydration of each individual hydroxyl group in the di- and trisaccharides is very similar to the hydration of the corresponding hydroxyl in the monomeric methyl alpha-D-mannoside. No hydrogen-bond interactions were found to stabilize the conformations of the alpha-(1,2)- and alpha-(1,6)-linkages and the chemical shifts for the hydroxy proton resonances of the alpha-(1,6)-linkage indicated high-conformational flexibility. For the alpha-(1,3)-linkage, however, the downfield shift for the signal of O(2)H of the 3-substituted residue together with the ROE between this proton and H5' on the next residue suggest some weak inter-residue interactions
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Mannosides
|2 NLM
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|a Oligosaccharides
|2 NLM
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| 650 |
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|a Protons
|2 NLM
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|a Kenne, Lennart
|e verfasserin
|4 aut
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|a Lahmann, Martina
|e verfasserin
|4 aut
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|a Oscarson, Stefan
|e verfasserin
|4 aut
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| 700 |
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|a Sandström, Corine
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 45(2007), 12 vom: 01. Dez., Seite 1076-80
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
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|g volume:45
|g year:2007
|g number:12
|g day:01
|g month:12
|g pages:1076-80
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|d 45
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