SLE serum induces classical caspase-dependent apoptosis independent of death receptors

SLE serum induces classical caspase-dependent apoptosis independent of death receptors

The main source of autoantigens in systemic lupus erythematosus (SLE) is most likely apoptotic material. We have previously shown that sera from SLE patients can induce apoptosis in monocytes and lymphocytes, and here we characterized mechanisms of apoptosis induced by SLE serum. SLE serum seems to...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 126(2008), 1 vom: 01. Jan., Seite 57-66
1. Verfasser: Bengtsson, Anders A (VerfasserIn)
Weitere Verfasser: Gullstrand, Birgitta, Truedsson, Lennart, Sturfelt, Gunnar
Format: Aufsatz
Sprache:English
Veröffentlicht: 2008
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Autoantigens Caspase Inhibitors FADD protein, human Fas-Associated Death Domain Protein Proto-Oncogene Proteins c-bcl-2 Receptors, Death Domain Receptors, Tumor Necrosis Factor, Type I fas Receptor mehr... Caspases EC 3.4.22.-