P38 mitogen-activated protein kinase mediates glucocorticoid receptor function induced by dexamethasone in acute lymphoblastic leukemia cells

OBJECTIVE: Glucocorticoid (GC) has occupied a central role in the treatment of acute lymphoblastic leukemia due to its ability to induce apoptosis in neoplastic lymphoid cells. Glucocorticoid resistance is present among 20% initial acute lymphoblastic leukemia, even 80% refractory acute lymphoblasti...

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Bibliographische Detailangaben
Veröffentlicht in:Zhonghua er ke za zhi = Chinese journal of pediatrics. - 1960. - 45(2007), 9 vom: 19. Sept., Seite 687-91
1. Verfasser: He, Li (VerfasserIn)
Weitere Verfasser: Li, Dan, Hou, Ke-Zuo, Liu, Yun-peng
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2007
Zugriff auf das übergeordnete Werk:Zhonghua er ke za zhi = Chinese journal of pediatrics
Schlagworte:Journal Article Enzyme Inhibitors Glucocorticoids Imidazoles NR3C1 protein, human Pyridines Receptors, Glucocorticoid Dexamethasone 7S5I7G3JQL Protein Serine-Threonine Kinases mehr... EC 2.7.11.1 Mitogen-Activated Protein Kinases EC 2.7.11.24 p38 Mitogen-Activated Protein Kinases SB 203580 OU13V1EYWQ